Knockdown of Tlr4 in the Arcuate Nucleus Improves Obesity Related Metabolic Disorders

Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders

Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body we...

Coexpression of gonadotropin inhibitory hormone with Agouti-related peptide in the neurons of arcuate nucleus of ewe hypothalamus

Introduction: Gonadotropin inhibitory hormone (GnIH) and Agouti-related peptide (AgRP) are orexigenic peptides expressed in the arcuate nucleus (Arc) of the hypothalamus in the ewe. In addition, effects of GnIH and AgRP on the regulation of gonadotropin releasing hormone secretion have been shown in some mammals. The objective of the present study was to investigate the coexpression of GnIH ...

Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders

Inflammation plays an important role in the development of obesity and metabolic disorders; however, it has not been fully understood how inflammation occurs and is regulated in their pathogenesis. Low-molecular mass protein-7 (LMP7) is a proteolytic subunit of the immunoproteasome that shapes the repertoire of antigenic peptides on major histocompatibility complex class I molecule. In this stu...

Role of Inflammation in Obesity Related Metabolic Disorders

Globally, obesity is a major contributor to the burden of several chronic metabolic diseases, including type 2 diabetes mellitus and cardiovascular diseases. With changing life style, obesity has now become a global phenomenon affecting all socioeconomic groups, irrespective of age, sex or ethnicity. Morbid obesity and co morbidities of metabolic syndrome, such as hypertension, dyslipidemia and...

Expression of RFamide-Related Peptide-3 (RFRP-3) mRNA in Dorsomedial Hypothalamic Nucleus and KiSS-1 mRNA in Arcuate Nucleus of Rat during Pregnancy